Noncoding Vault RNA1-1 Impairs Intestinal Epithelial Renewal and Barrier Function by Interacting With CUG-binding Protein 1Summary

Background & Aims: Small noncoding vault RNAs (vtRNAs) are involved in many cell processes important for health and disease, but their pathobiological functions in the intestinal epithelium are underexplored.Here, we investigated the role of human vtRNA1-1 in regulating intestinal epithelial renewal and barrier function.Methods: Studies were co

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Assessment of Cell Viability in Drug Therapy: IC50 and Other New Time-Independent Indices for Evaluating Chemotherapy Efficacy

Background/Objectives: Cell viability assays play a crucial role in cancer research and the development of effective treatments.Evaluating the efficacy of conventional treatments across different tumor profiles is essential for understanding patient resistance to chemotherapy and relapse.The IC50 index has been commonly used as a guide in these ass

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Prefrontal control of attention to threat

Attentional control refers to the regulatory processes that ensure that our actions are in accordance with our goals.Dual-system accounts view temperament as consisting of both individual variation in emotionality (e.g.trait anxiety) and variation in regulatory attentional mechanisms that Baking Tray act to modulate emotionality.Increasing evidence

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